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目的 :研究腺苷在白细胞介素 - 1诱导的大鼠行为性抑郁中的作用。方法 :应用Porsolt游泳试验观察大鼠脑室注射白介素 - 1β引起的行为性抑郁 ,通过注射非特异性腺苷受体拮抗剂咖啡因和特异性A1和A2腺苷受体拮抗剂 ,确定脑内腺苷在白细胞介素 - 1β引起的大鼠行为性抑郁中的作用以及介导这种作用的受体。结果 :脑内注射白细胞介素 - 1β(8- 32ng/kg ,icv)可导致大鼠在Porsolt游泳试验中漂浮时间明显地延长 ,非特异性腺苷受体拮抗剂咖啡因 (7mg/kg ,ip)和特异性A2a腺苷受体拮抗剂 (1mg/kg ,ip)预处理能够缩短漂浮时间的延长。结论 :脑内注射白细胞介素 - 1β可引起大鼠的行为性抑郁 ,脑内腺苷通过A2a受体介导白细胞介素 - 1β的这种作用
AIM: To investigate the role of adenosine in behavioral depression induced by interleukin - 1 in rats. Methods: Porsolt swimming test was used to observe behavioral depression induced by intracerebroventricular injection of interleukin - 1β in rats. The intracerebral adenosine was determined by injection of non - specific adenosine receptor antagonist caffeine and specific A1 and A2 adenosine receptor antagonists Role in interleukin - 1β - induced behavioral depression in rats and receptors mediating this effect. RESULTS: Intrathecal injection of interleukin-1β (8-32 ng / kg, icv) resulted in a significant prolongation of floating time in the Porsolt swimming test. The nonspecific adenosine receptor antagonist caffeine (7 mg / kg ip ) And specific A2a adenosine receptor antagonist (1mg / kg, ip) can shorten the lengthening of floating time. CONCLUSION: Intracerebral injection of interleukin - 1β causes behavioral depression in rats, and this effect of intraceranosine adenosine mediated interleukin - 1β mediated by A2a receptor