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类风湿关节炎(RA)是一种慢性、进行性自身免疫性疾病,RA患者血清中可检测到多种自身抗体,包括类风湿因子(RF)、抗环瓜氨酸肽(CCP)抗体和抗突变型瓜氨酸波形蛋白(MCV)抗体等。RF是最早用于RA诊断的血清学指标,存在于60%的RA患者血清中[1],但在其他免疫性疾病、感染性疾病、恶性肿瘤中也可存在,因此特异性偏低[2]。抗CCP抗体是近年来新发现的RA自身抗体,对RA诊断有较高的敏感性和特异性,且在疾病早期即可出现,因此对早期RA诊断有很高价值[3]。此外,抗CCP抗体还可作为RA骨侵蚀发生与否的预测指标,用于判断RA的预后,对临床治疗有很重要的指导意义[4]。最近,有研究报道抗MCV抗体对RA的诊断价值更
Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease that has multiple autoantibodies detected in the serum of RA patients, including rheumatoid factor (RF), anti-cyclic citrullinated peptide (CCP) antibodies and Anti-mutant citrullinated vimentin (MCV) antibodies and the like. RF is the earliest serological marker for the diagnosis of RA and is present in 60% of sera of RA patients [1], but is also found to be low in other immunological, infectious and malignant tumors [2 ]. Anti-CCP antibodies are newly discovered autoantibodies to RA in recent years. They are highly sensitive and specific for the diagnosis of RA and appear early in the disease. Therefore, anti-CCP antibodies are of great value in the diagnosis of early RA [3]. In addition, anti-CCP antibody can also be used as a prediction index of RA bone erosion, which can be used to judge the prognosis of RA, which is of great significance for clinical treatment [4]. Recently, some studies have reported that anti-MCV antibodies are more valuable for the diagnosis of RA