传统的肿瘤治疗方式主要分为化疗、放疗和手术治疗。手术与放疗在侵袭性肿瘤转移中应用受限,而细胞毒类化疗药物缺乏对肿瘤细胞选择性,已逐渐被淘汰。随着分子水平对肿瘤发病机制认识的深入,有效的癌症治疗手段已转变为对信号传导通路干预的高选择性靶向药物。它通过抑制分子信号通路中的特定靶点来阻止肿瘤的生长与转移,避免了对正常组织的损伤,获得了良好的预期临床效果。因此,基于对不同靶点的抗肿瘤研究已经成为当前 The traditional treatment of cancer is divided into chemotherapy, radiotherapy and surgical treatment. Surgery and radiotherapy are limited in invasive tumor metastasis, and cytotoxic chemotherapy drugs are less selective for tumor cells and have gradually been eliminated. With the understanding of the molecular level on the pathogenesis of cancer, effective cancer treatment has been transformed into highly selective targeted drugs that interfere with signal transduction pathways. It inhibits tumor growth and metastasis by inhibiting specific targets in molecular signaling pathways, avoids the damage to normal tissues and achieves good expected clinical effects. Therefore, antitumor research based on different targets has become current