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为了观察抗胸腺淋巴细胞球蛋白(ATG)的免疫抑制效果,将肾移植术后单独应用环孢素A(CsA)和术后早期小剂量应用ATG的各200例患者作了比较,结果CsA组发生急性排斥反应(AR)46例次(23%),逆转41例(89.1%);ATG组发生AR33例(16.5%),逆转31例(93.9%)。肾功能在2~10天恢复正常的,CsA组为84例(42%),ATG组为159例(79.5%);肾移植后合并感染,CsA组36例,ATG组18例;CsA组摘肾8例,ATG组4例;CsA组死亡5例,ATG组3例。本组资料提示小剂量ATG的应用对延长肾移植后存活时间有重要意义
In order to observe the immunosuppressive effect of anti-thymus lymphocyte globulin (ATG), 200 patients who received cyclosporine A (CsA) alone and small early postoperative ATG after renal transplantation were compared. Results CsA group Acute rejection (AR) 46 cases (23%), reversal of 41 cases (89.1%); ATG group AR33 cases (16.5%), 31 cases of reversal (93.9%). Renal function returned to normal after 2 to 10 days, 84 cases (42%) in CsA group and 159 cases (79.5%) in ATG group, 36 cases in CsA group, 18 cases in ATG group and CsA 8 cases were kidneys from kidney and 4 cases from ATG. 5 cases died from CsA and 3 cases from ATG. The data suggest that the application of low-dose ATG to extend the survival time after renal transplantation is important