子宫内膜在月经周期及妊娠期均有丰富的趋化因子表达,趋化因子可募集外周血淋巴细胞至内膜,并影响其分裂及活化,通过对局部淋巴细胞亚群的构成及功能调控,间接参与月经形成及妊娠维持。同时母胎界面生成的趋化因子还可以自分泌或旁分泌的方式调节滋养细胞的增殖、分化及侵袭,可能参与胎盘血管重铸、胎盘发生及局部血管生成等生理过程。 Endometrium in the menstrual cycle and pregnancy are rich in chemokine expression, chemokines can raise peripheral blood lymphocytes to the intima, and affect their division and activation of the local lymphocyte subsets by the composition and function of regulation , Indirectly involved in the formation of menstruation and pregnancy maintenance. At the same time, the chemokines produced at the maternal-fetal interface can regulate the proliferation, differentiation and invasion of trophoblasts in an autocrine or paracrine manner, which may be involved in physiological processes such as placental vascular recanalization, placentation and local angiogenesis.