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应用武汉生物制品研究所生产的10μg 剂量加热灭活(100℃2分钟)乙肝疫苗,按0-1-3月免疫方案接种新生儿。免后1个月抗-HBs 阳转率为94.1%、S/N 均值为51.1。与同剂量上海生物制品研究所生产的化学灭活乙肝疫苗免疫效果阳转率93.1%,S/N 均值52.6相比较,经统计学处理两种乙肝疫苗的阳转率和S/N 均值均无显著性差异(P>0.05)。表明加热灭活乙肝疫苗的免疫原性与化学灭活疫苗相似,两组观察对象均未检出HBsAg,疫苗是安全的。对经上海所乙肝疫苗全程免疫后2个月检测抗-
Application of 10μg dose of Wuhan Institute of Biological Products heat inactivated (100 ℃ 2 minutes) hepatitis B vaccine, according to 0-1-3 month immunization programs vaccination of newborns. The anti-HBs positive rate was 94.1% at one month after immunization, and the S / N mean was 51.1. Compared with the positive rate of immunization effect of chemical inactivated hepatitis B vaccine and the mean S / N ratio of 52.6 produced by the same dose of Shanghai Institute of Biological Products, the positive rate and S / N mean of the two kinds of hepatitis B vaccine Significant difference (P> 0.05). The results showed that the immunogenicity of Hep-inactivated hepatitis B vaccine was similar to that of chemical inactivated vaccine. No HBsAg was detected in the two groups, and the vaccine was safe. 2 months after the whole course of the Hepatitis B vaccine was tested in Shanghai,