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15(S)-15-甲基前列腺素F_(2α)(15-甲基PGF_(2α))和催产素,能使以高钾处理的早孕小鼠部分去极化离体子宫平滑肌的张力增高,其作用随两药浓度上升而增大。戊脉安能抑制两药的收缩效应,其抑制作用随戊脉安浓度的提高而增加,当戊脉安浓度达到5×10~(-4)M 时,收缩效应完全被抑制。此外,在无钙溶液中,15-甲基PGF_(2α)和催产素都不能引起部分去极化子宫平滑肌的收缩效应。从而提示钙的内流机制在15-甲基PGF_(2α)和催产素所引起的去极化子宫肌的收缩效应中起了重要的作用。
15 (S) -15-methyl prostaglandin F_ (2α) (15-methyl PGF_ (2α)) and oxytocin can partially depolarize the tension of isolated uterine smooth muscle in early pregnant mice treated with high potassium , Its role with the concentration of two drugs increased. Verapamil can inhibit the contractile effect of the two drugs, and its inhibitory effect increases with the increase of verapamil. When the verapamil concentration reaches 5 × 10 ~ (-4) M, the contractile effect is completely inhibited. In addition, none of the 15-methyl PGF_ (2α) and oxytocin induce a partial depolarization of uterine smooth muscle in the calcium-free solution. Suggesting that the calcium influx mechanism plays an important role in the contractile effect of depolarized uterine muscle caused by 15-methyl PGF 2α and oxytocin.