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目的了解某部人群肾综合征出血热(HFRS)流行特征及其感染型别,为本病防治工作提供科学依据。方法收集某部的疫情资料及相关信息资料,进行整理分析。同时采集HFRS疫区近期患者血清,应用RT-nested PCR结合SSCP对病人血清进行基因分型。结果某部1991-2006年报告病例403例,以散发为主,仅个别情况下长期密切接触疫源地才偶见局灶性暴发。报告病例呈现逐年下降趋势,2001年后呈零星散发;病例多集中在C、G、M等单位;以20～40岁发病居多;患者以战士为主,占72.21%;发病季节以春夏季高峰为主。基因分型结果证实当地近年来HFRS疫区从HTN向SEO转变,目前已经演变成以SEO为主的疫区。结论基本摸清某部近年HFRS流行特征,基因分型证实当地已经演变成以SEO为主的混合型疫区。
Objective To understand the prevalence and infection type of hemorrhagic fever with renal syndrome (HFRS) in a certain population and provide a scientific basis for the prevention and treatment of this disease. Methods Collecting epidemic information and related information of a certain department and sorting out the data. At the same time, the serum of patients with recent HFRS epidemic was collected, and the patient’s serum was genotyped by RT-nested PCR combined with SSCP. Results A total of 403 cases reported in 1991-2006 were distributed mainly in the meantime. Only a few cases of focal outbreak occasionally occurred in close contact with the epidemic area in a few cases. Reported cases showed a downward trend year after year, was sporadic sporadic; cases are more concentrated in the C, G, M and other units; most of the incidence of 20 to 40-year-old; patients mainly fighters, accounting for 72.21%; onset season to spring and summer peak Mainly. Genotyping results confirmed that the local epidemic of HFRS from HTN to SEO in recent years has evolved into an SEO-dominated epidemic area. Conclusions The basic characteristics of HFRS epidemic in a certain area in recent years have been ascertained. Genotyping confirmed that the area has evolved into a mixed type epidemic area dominated by SEO.