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①目的了解肝癌病人癌与癌旁组织中雄激素受体(AR)的改变。②方法用葡聚糖包裹活性炭饱和吸附法(DCC法)检测21例肝细胞癌(HCC)癌组织和癌旁组织中AR,并与7例男性肝硬变病人肝组织中的AR进行了比较。③结果癌组织中AR的含量显著高于癌旁组织(t=2.793,P<0.01)及硬变肝组织(t=2.323,P<0.05)。④结论AR的增加与肝细胞的恶变有关,从而为HCC的内分泌治疗提供分子生物学依据。
Objective To understand the changes of androgen receptor (AR) in cancer and adjacent tissues of patients with hepatocellular carcinoma. 2Methods AR was detected with dextran-encapsulated activated carbon saturated adsorption (DCC) in 21 cases of hepatocellular carcinoma (HCC) cancer tissues and paracancerous tissues, and compared with AR in liver tissues of 7 male cirrhosis patients. . 3 Results The content of AR in cancer tissues was significantly higher than that in adjacent tissues (t=2.793, P<0.01) and in hardened liver tissues (t=2.323, P<0.05). 4 Conclusion The increase of AR is related to the malignant transformation of hepatocytes, thus providing a molecular biological basis for the endocrine therapy of HCC.