论文部分内容阅读
二巯基丙醇在中国药典中已采为法定药。关于此物的化学,包括发明的经过,制造与精制的各种方法,以及其水溶性的衍生物,和结构与作用的关系,我们会根据文献有一综合性的报道,文内可查得有关这方面的其他原文文献之所在。在此报道的最后一段,我们会报告我们以适合国情的方法合成成功。现将其详情报告如下按二巯基丙醇的制取法,一般都利用下列反应:据已往文献,用2:3氯代丙醇不及用2:3溴代丙醇顺利,且前者的制取也较后者困难。至于硫氢化鹼,国外几乎全用钠盐,未闻试过钾盐,硫氢化铔倒有人用过,据说成绩不好。反应溶剂有的用甲醇,也有的用乙醇。
Dimercaptopropanol has been adopted as a statutory drug in the Chinese Pharmacopoeia. The chemistry of this substance, including the process of invention, various methods of manufacturing and refining, and its water-soluble derivatives, and the relationship between structure and action, we will have a comprehensive report according to the literature, which can be found in the article This is where other source texts are located. In the last paragraph of this report, we will report that we have succeeded in synthesizing our country’s situation. The details of this report are as follows: According to the preparation method of dimercaptopropanol, the following reactions are generally used: According to the past literature, the use of 2:3 chloropropanol is less successful than the use of 2:3 bromopropanol, and the former is prepared. It is also more difficult than the latter. As for hydrogen sulfide bases, almost all of them use sodium salt in foreign countries, and no potassium salt has been tried. Some people used sulfur hydride, and it is said that the results are not good. Some of the reaction solvent used methanol, and some use ethanol.