论文部分内容阅读
子宫内膜异位症(endometriosis,EM)是常见的妇科良性疾病,但其具有如侵袭生长、远处转移和易复发等恶性生物学行为。众多研究从遗传、分子、发生率等多层面验证了EM和与Ⅰ型卵巢癌密切相关。除了年龄、病程、月经和生育情况等因素,EM的恶变还与炎症和基因突变相关。恶变的患者具有年轻、诊断期别早、铂类敏感性和手术满意率较高、生存预后较好的特点。本文从流行病学、组织病理、非典型EM和临床诊治方面进行一综述,旨在提高临床医生对EM恶变的认识和重视程度,为EM恶变的临床诊治提供参考。
Endometriosis (EM) is a common gynecological benign disease, but it has malignant biological behaviors such as invasive growth, distant metastasis and relapse. Numerous studies have demonstrated that EM is closely related to type I ovarian cancer from the aspects of genetics, molecular and incidence. In addition to age, duration, menstruation and fertility and other factors, EM malignant transformation is also associated with inflammation and genetic mutations. Malignant patients with young, early diagnosis, platinum sensitivity and surgical satisfaction rate, better survival prognosis characteristics. This article reviews the epidemiology, histopathology, atypical EM and clinical diagnosis and treatment in order to improve clinicians’ understanding and emphasis on EM malignant transformation and provide reference for the clinical diagnosis and treatment of EM malignant transformation.