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鲍精子细胞溶素(lysin)是所有动物繁殖蛋白中了解的最透彻的一种,作为一种非酶蛋白质,lysin可在卵黄膜上特异性地钻1个孔使精子从此孔进入。目前对lysin的研究主要集中在它的结构、生化、功能和进化等方面:lysin是一种由2个单体组成的二聚体分子,其单体为5个-α螺旋组成的螺旋束,lysin以二聚体形式与其糖蛋白受体(VERL)特异性结合,然后单体化,再与受体非特异性结合,这与普通动物细胞表面的分子识别的相关内容相一致;许多鲍lysin的氨基酸序列已经测定出来,并证实lysin是通过正向选择方式进化的,对于其进化的模式也有假设来说明,这对理解海洋新种的形成具有重要作用。
As a non-enzymatic protein, lysin can specifically penetrate one hole in the yolk membrane to allow sperm to enter the well. The current research on lysin mainly focuses on its structure, biochemistry, function and evolution. Lysin is a dimeric molecule composed of two monomers, the monomer is a helical bundle consisting of five α-helices, Lysin binds specifically to its glycoprotein receptor (VERL) as a dimer and then monomerizes, which in turn is nonspecifically bound to the receptor, consistent with molecular recognition on the cell surface of common animals; many Lysins Amino acid sequences have been determined and confirmed that lysin evolves through forward selection and is also hypothesized for its evolutionary pattern, which plays an important role in understanding the formation of marine species.