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Two monocarbonyl analogs of curcumin containing bis(2,6-difluorobenzyl) were synthesized,and their molecular structures were characterized by 1H NMR,ESI-MS,and X-ray crystallography.In this paper,the crystal structures of these two analogs(A75 and C75) are described and compared with their bis(2-fluorobenzyl) analogues as well as with the available data of curcumin.The cyclopentane rings in A75 have an envelope conformation,while the cyclohexane ring in C75 has a chair conformation.The compounds are symmetrical and the central structure of A75 and C75 connects with two benzylidene rings through E,E-oriented double bonding.
Two monocarbonyl analogs of curcumin containing bis (2,6-difluorobenzyl) were synthesized, and their molecular structure were characterized by 1H NMR, ESI-MS, and X-ray crystallography. In this paper, the crystal structures of these two analogs and C75) are described and compared with their bis (2-fluorobenzyl) analogues as well as with the available data of curcumin. The cyclopentane rings in A75 have an envelope conformation, while the cyclohexane ring in C75 has a chair conformation.The compounds are symmetrical and the central structure of A75 and C75 connects with two benzylidene rings through E, E-oriented double bonding.