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淡漠是帕金森病重要的非运动症状之一,与运动症状及多种非运动症状相关,对帕金森病预后有一定预测意义。目前认为帕金森病淡漠的机制为前额叶-基底节神经环路多巴胺能神经元损害,但是具体发生机制仍待阐明。近年来神经影像学结合不同的分析方法被应用在帕金森病淡漠机制的研究,能客观、间接地反映大脑结构和功能活动异常,为解释其机制提供一定线索,本文对帕金森病淡漠的神经影像学进展做一综述。“,”As one of the essential non-motor symptoms in Parkinson′s disease(PD), apathy is associated with both motor symptoms and other non-motor symptoms and contributes significantly to the prognosis of PD. Apathy is thought to be related to dopaminergic dysfunction in prefrontal-basal ganglia circuits. However, its precise neural bases remain unclear. Many neuroimaging studies using different analyses have been conducted to study the underlying neural mechanisms of apathy in PD. This review will describe the current understanding of the structural and functional changes associated with apathy in PD patients.