中药补益剂的药理研究尤其是免疫药理研究具有重要理论和实际意义，但根据中医理论，中药补益剂的深入研究需要适当的虚证动物模型，现有的脾气虚模型具有造模难、重复性差、与国际上相应学科难以接轨的缺点。一、本研究包括1．建立一个稳定的具有中医脾气虚证型表现的环磷酷胺 Pharmacological research of traditional Chinese medicine supplements, especially immunopharmacological research, has important theoretical and practical significance. However, according to the theory of traditional Chinese medicine, the in-depth study of traditional Chinese medicine supplements needs appropriate animal models for deficiency syndromes. The existing temper-deficiency models have difficulties in model building and poor reproducibility. , with the international counterparts difficult to meet the shortcomings. First, this study includes 1. Establish a stable cyclophosphamide that has the symptoms of spleen deficiency syndrome in Chinese medicine