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目的了解家兔及大鼠吸入全氟异丁烯(PFIB)后血液中氟离子(F~-)浓度的变化。方法家兔6只,雌雄各半;大鼠48只,雌雄各半,随机均分为8组。在动物动态染毒装置中,家兔头部暴露染毒20 min,染毒浓度为(0.300±0.005)mg/L;大鼠头部暴露8 min,染毒浓度为(0.150±0.005)mg/L。测定家兔染毒前和染毒后0、3、6、12、24h时血液中F~-浓度;分别测定大鼠染毒前和染毒后0、0.5、1.0、1.5、2.0、2.5、3.0h时血液中F~-浓度。结果与染毒前比较,家兔及大鼠染毒后即刻血液中F~-浓度明显升高,差异有统计学意义(P<0.01)。大鼠染毒后0.5和1.0 h血液中F~-浓度仍明显高于染毒前,差异有统计学意义(P<0.05);至染毒后1.5 h血液中F~-浓度与染毒前基本一致。结论PFIB被动物吸入后迅速与体内物质作用,产物中有可解离出F~-的产物,血液中F~-浓度升高可为临床提供诊断依据。
Objective To investigate the changes of F - concentration in blood after inhalation of perfluoroisobutylene (PFIB) in rabbits and rats. Methods Six rabbits, half male and half female, were randomly divided into 8 groups. In the dynamic animal exposure device, the rabbit head exposed to exposure for 20 min exposure concentration (0.300 ± 0.005) mg / L; the head exposed to rats for 8 min, the exposure concentration (0.150 ± 0.005) mg / L. The concentrations of F ~ - in blood were measured before and at 0, 3, 6, 12 and 24 hours after exposure in rats. The levels of F ~ - in blood were measured before and at 0,0.5,1.0,1.5,2.0,2.5, 3.0h blood F ~ - concentration. Results Compared with those before exposure, the F - concentration in blood of rabbits and rats was significantly increased immediately after exposure (P <0.01). The concentrations of F ~ - in blood at 0.5 and 1.0 h after exposure were still significantly higher than those before exposure (P <0.05) Basically the same. Conclusions PFIB is rapidly absorbed by animals and interacts with the substance in vivo. The products of PFIB can be dissociated from F ~ -, and the increase of F - concentration in blood can provide the basis for clinical diagnosis.