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目的探讨妊娠对兔骨折愈合内分泌改变的影响。方法日本大耳白雌兔随机分组,妊娠组孕后9d各组造模,按造模前、造模后即时、造模后1、2、3周各时点抽取耳缘静脉血或心穿血,提取血清后-80℃冻存,送检生长激素、骨钙素,其数据行统计学检验。结果妊娠组造模后即时、造模后1、2、3周血清生长激素值[(1.33±0.07)、(1.43±0.02)、(1.51±0.11)、(1.83±0.29)ng/ml]高于对照组[(1.21±0.15)、(1.32±0.10)、(1.25±0.19)、(1.34±0.31)ng/ml](P<0.05);骨钙素值[(0.50±0.05)、(0.54±0.03)、(0.59±0.08)、(0.64±0.05a)ng/ml]高于对照组[(0.41±0.67)、(0.44±0.08)、(0.50±0.035)、(0.55±0.04)ng/ml](P<0.05)。结论兔早中期妊娠可能对骨折愈合有促进作用。
Objective To investigate the effect of pregnancy on endocrine changes of fracture healing in rabbits. Methods The Japanese white male rabbits were randomly divided into groups. Pregnancy group was established on the 9th day of gestation, and the rabbits in each group were made models immediately before modeling and immediately after model making. Ear vein or heart puncture Blood, serum extracted after -80 ℃ frozen, submitted for growth hormone, osteocalcin, the data line statistics. Results The gestational age of the pregnancy group was significantly higher than that of the control group (P <0.01) (1.21 ± 0.15), (1.32 ± 0.10), (1.25 ± 0.19), (1.34 ± 0.31) ng / ml] in the control group (P <0.05) (0.41 ± 0.67), (0.44 ± 0.08), (0.50 ± 0.035), (0.55 ± 0.04) ng / ml] were significantly higher than those in the control group ml] (P <0.05). Conclusion Early and mid-term pregnancy in rabbits may promote fracture healing.