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作者们从13例患系统性红斑狼疮的病人肾脏活检材料,进行光学显微镜、电子显微镜及免疫萤光显微镜检查,研究这些形态学的变化与蛋白尿及肾功能的关系。光镜检查显示:弥漫性增殖性狼疮肾炎6例,膜性狼疮性肾炎2例,间质性狼疮性肾炎4例,膜性增殖性肾小球肾炎1例。电镜下高电子密度物质沉着在系膜或间质、上皮与基底膜之间、内皮细胞下与基底膜之间,以及肾小球外肾小管的基底膜Bowman囊壁、间质组织和肾小管周围的毛细血管等部位。肾小球外沉着是预后差的征兆。11例萤光显微镜检查,在肾小球间质显示有IgG 7例,IgM 3例,IgA 2例,
The authors examined the relationship between these morphological changes and proteinuria and renal function from 13 renal biopsy specimens of patients with systemic lupus erythematosus, using light microscopy, electron microscopy and immunofluorescence microscopy. Light microscopy showed: diffuse proliferative lupus nephritis in 6 cases, membranous lupus nephritis in 2 cases, interstitial lupus nephritis in 4 cases, membranous proliferative glomerulonephritis in 1 case. Electron microscopy of high electron density deposition in the mesangial or interstitial epithelial and basement membrane between the endothelial cells and the basement membrane, as well as the glomerular basement membrane of the tubular membrane Bowman’s wall, interstitial tissue and tubular Around the capillaries and other parts. Glomerular degeneration is a sign of poor prognosis. Eleven cases of fluorescent microscopy showed glomerular interstitial IgG 7 cases, IgM 3 cases, IgA 2 cases,