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活体移植从肝脏分离的肝细胞,并期望发挥其功能的尝试,始于糖尿病动物移植胰岛细胞试验成功之后的1972年。从1975年到1977年间,在美国的明尼苏达大学外科,瑞典的卡罗林斯卡研究所外科以及本文作者所在的日本旭川医大第二外科都报告了肝细胞移植实验,欧美两组使用的动物是大致相同的实验系,其具体方法是从具有UDPGT(尿核甙二磷酸葡萄糖醛酰移换酶)的大鼠中采取肝细胞,把此肝细胞移植到因先天
In vivo transplantation of liver cells isolated from the liver and an attempt to exert their function began in 1972 after the successful transplantation of diabetic islet cells by islet cells. From 1975 to 1977, liver cell transplantation experiments were reported in the surgery of the University of Minnesota in the United States, the Karolinska Institute in Sweden, and the second surgical department of Asahikawa University in Japan. The animals used in both Europe and the United States were Approximately the same experimental line is obtained by taking hepatocytes from a rat having UDPGT (uridine nucleoside diphosphate glucuronyltransferase) and transplanting the hepatocytes into cells that are congenital