胰岛素抵抗是一种状态,即正常或高于正常浓度的胰岛素却只能引起低于正常的生物效应。本文分析引起胰岛素抵抗的各种原因。 在理论上,胰岛素抵抗可以分为以下三种情况:胰岛素到达靶细胞之前异常(受体前缺陷),传递胰岛素作用的细胞受体水平的异常(受体缺陷),靶细胞内异常,在胰岛素受体水平之后(受体后缺陷)。如附表所示。 Insulin resistance is a condition in which normal or above-normal concentrations of insulin cause only subnormal biological effects. This article analyzes the various causes of insulin resistance. In theory, insulin resistance can be classified into the following three cases: an abnormality of insulin before it reaches a target cell (pre-receptor defect), an abnormality of the receptor level of receptor of insulin transmitting a receptor (receptor defect), an abnormal target cell, After receptor level (post-receptor defect). As shown in the attached table.