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目的 :观察不同周期诱导化疗及放疗对局部晚期非小细胞肺癌 (NSCLC)疗效和毒性的影响。方法 :5 1例经病理证实的NSCLC分为诱导化疗≤ 3周期 (A组 )和 >3周期 (B组 ) ,分别加常规放疗DT 5 0～ 70Gy 5～ 7周。 结果 :A、B两组近期有效率分别为 6 9.2 %和 6 8.0 % (P >0 .0 5 ) ;3年生存率分别为 11.5 %和 12 .0 % (P >0 .0 5 ) ;Ⅲ～Ⅳ级消化道反应分别为 3.8%和 2 0 .0 % (P >0 .0 5 ) ;Ⅲ～Ⅳ级骨髓抑制分别为 7.7%和 36 .0 % (P <0 .0 5 )。结论 :不同周期诱导化疗加放疗对局部晚期NSCLC的疗效相当 ,但≤ 3周期毒性明显减低。
Objective: To observe the effects of different cycles of induction chemotherapy and radiotherapy on the efficacy and toxicity of locally advanced non-small cell lung cancer (NSCLC). Methods: Fifty-one patients with NSCLC confirmed by pathology were divided into induction chemotherapy of ≤ 3 cycles (group A) and> 3 cycles (group B). The patients were treated with conventional radiotherapy for 5 ~ 70 Gy for 5-7 weeks. Results: The effective rates of the two groups were 62.2% and 68.0%, respectively (P> 0.05). The 3-year survival rates were 11.5% and 12.0% (P> 0.05), respectively. The grade Ⅲ ~ Ⅳ digestive tract reactions were 3.8% and 20.0% (P> 0.05) respectively. The grade Ⅲ ~ Ⅳ myelosuppression was 7.7% and 36.0%, respectively (P <0.05). Conclusion: Different cycles of induction chemotherapy and radiotherapy have the same curative effect on locally advanced NSCLC, but the toxicity of ≤ 3 cycles is obviously reduced.