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目的 研究氧化性肺损伤在成人呼吸窘迫综合征 (ARDS)发病中的作用及维生素E和二甲亚砜的抗氧化保护作用。方法 将 2 8只大鼠随机分成 4组 :油酸组、VE组、DMSO组、正常对照组。油酸于尾静脉注入 ,维生素E和二甲亚砜由腹腔注射。注油酸后 2h观察肺系数 ,肺组织MDA含量、PaO2 及肺组织病理改变。结果 VE组和DMSO组较油酸组肺系数、MDA含量降低 (P <0 0 5 ) ,PaO2 升高 (P <0 0 5 ) ,肺组织病理改变明显减轻。结论 氧化性肺损伤参与油酸型ARDS的发病 ,维生素E和二甲亚砜具有保护作用
Objective To investigate the role of oxidative lung injury in the pathogenesis of adult respiratory distress syndrome (ARDS) and the antioxidative protection of vitamin E and dimethyl sulfoxide. Methods 28 rats were randomly divided into 4 groups: oleic acid group, VE group, DMSO group, normal control group. Oleic acid in the tail vein injection, vitamin E and dimethyl sulfoxide by intraperitoneal injection. 2h after oleic acid injection observed pulmonary coefficient, MDA content in lung tissue, PaO2 and lung tissue pathological changes. Results Compared with oleic acid group, the pulmonary function and the content of MDA in VE group and DMSO group decreased (P <0 05) and PaO2 increased (P 0 05), and the pathological changes of lung tissue in VE group and DMSO group decreased significantly. Conclusions Oxidative lung injury is involved in the pathogenesis of oleic acid-type ARDS, with protective effects of vitamin E and dimethyl sulfoxide