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目的探讨多囊卵巢综合征(PCOS)患者进行体外受精-胚胎移植治疗时控制性超排卵方案的选择。方法回顾性分析216例PCOS患者,促排卵方案分别为长方案A组(56例)、超长方案B组(42例)、改良超长方案C组(54例)及拮抗剂方案D组(64例),分析比较各组患者资料。结果 4组患者一般情况、人绒毛膜促性腺激素注射日(HCG日)血清激素水平和获卵数类似;D组的促性腺激素(Gn)总量、Gn天数均低于B组和C组;D组的受精率、优质胚胎数及优质囊胚数均高于A组和C组。结论拮抗剂方案能缩短治疗时间、减少治疗费用,简单灵活,方便患者,可提高卵子和胚胎质量,减少并发症,安全性和有效性较好,是PCOS患者的理想选择。
Objective To investigate the choice of controlled ovarian hyperstimulation in patients with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization and embryo transfer. Methods A total of 216 patients with PCOS were retrospectively analyzed. The ovulation induction schedule was as follows: long-term plan A group (56 cases), long-term plan group B (42 cases), modified long-term plan group C (54 cases) and antagonist program D 64 cases), analysis and comparison of patient data in each group. Results The serum hormone level on HCG day was similar to the number of oocytes retrieved on the day of human chorionic gonadotropin injection (HCG). The total amount of gonadotropin (Gn) and the number of Gn days in group D were lower than those in group B and C ; Group D fertilization rate, the number of high-quality embryos and high-quality blastocysts were higher than the A and C groups. Conclusions Antagonist regimen can shorten the treatment time, reduce the cost of treatment, simple and flexible, convenient for patients, can improve the quality of eggs and embryos, reduce complications, safety and effectiveness of PCOS patients is ideal.