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作者用随机双盲对照试验评价.静脉内注射马雌激素对功能性子宫出血(功血)的疗效,研究包括34名病人,均主诉有过多或延长的阴道出血,病人经体检及妇产科检查排除有卵巢、子宫、宫颈器质性病变或有激素依赖性肿瘤,疑为妊娠及血小板凝集失调者.将病人随机分为二组,18例静脉内注射马雌激素(马雌激素25mg与乳糖200mg、枸椽酸钠12.5mg、二甲基硅油0.2mg相混,并以NaOH或HCl调节pH),16例静注安慰剂(乳糖200mg与枸椽酸钠12.5mg、二甲基硅油0.2mg,Carmel 1.8mg相混,用NaOH或HCl调节pH).以上马雌激素或安慰剂置于葡萄糖盐水中作静脉注射.二组病人年龄、身高、体重、出血时间及心率、血压、呼吸率及妇产科史等均相似.在注射前及注射
The authors evaluated with a randomized, double-blind, controlled trial of the effect of intravenous equine estrogen on functional uterine bleeding (dysfunctional uterine bleeding). The study included 34 patients, both of whom complained of excessive or prolonged vaginal bleeding. Subject examination ovariectomized, uterine, cervical lesions or hormone-dependent cancer, suspected pregnancy and platelet aggregation disorders. The patients were randomly divided into two groups, 18 cases of intravenous injection of equine estrogen (equine estrogen 25mg And lactose 200mg, sodium citrate 12.5mg, dimethicone 0.2mg mixed with NaOH or HCl pH), 16 patients intravenous placebo (lactose 200mg and sodium citrate 12.5mg, dimethyl silicone oil 0.2mg, Carmel 1.8mg, adjust the pH with NaOH or HCl) .The estrogen or placebo was placed in glucose saline for intravenous injection.The two groups of patients age, height, weight, bleeding time and heart rate, blood pressure, breathing Rate and obstetrics and gynecology history are similar in the injection and injection