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目的:研究三种染色与胃癌异质性和淋巴结转移的关系。方法:应用CD41免疫组化染色、AgNOR染色、HE染色三种方法染色胃癌的原发病灶与淋巴结移癌作对比观察分析。结果:在不同种类和分化程度的胃癌原发病灶和淋巴结转移病灶CD44蛋白表达率、AgNOR颗粒数、多核和巨核癌细胞的比较有明显的差异。结论:结果提示在肿瘤的诊断和治疗中必需考虑肿瘤的异质性。
Objective: To study the relationship between three kinds of staining and gastric cancer heterogeneity and lymph node metastasis. Methods: CD41 immunohistochemical staining, AgNOR staining, HE staining were used to stain the primary lesion of gastric cancer and lymph node metastasis for comparative observation and analysis. Results: There were significant differences in the expression of CD44 protein, AgNOR particle number, multi-nuclear and giant-cell cancer cells between primary lesions and lymph node metastasis of gastric cancer with different types and degree of differentiation. Conclusion: The results suggest that tumor heterogeneity must be considered in the diagnosis and treatment of tumors.