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目的 测量婴儿肝炎综合征患儿急性期和恢复期血清免疫球蛋白 G(Ig G)、免疫球蛋白 A(Ig A)、免疫球蛋 M(Ig M)、补体 C3、补体 C4和一氧化氮 (NO)水平 ,以了解各因素的变化及其相互关系以及与疾病进展的关系。方法 Ig G、Ig A、Ig M、C3、C4速率散射比浊法。NO终点法。结果 急性期婴肝患儿血清中 Ig G,Ig A及 C3含量显著降低 ,NO水平显著升高 ;恢复期和急性期相比 ,患儿血清中 Ig G、Ig M、Ig A、C3各指标均有所升高 ,但除 Ig M外各指标均较正常对照低 ;NO有所下降但仍高于正常对照。在疾病变化过程中Ig G、Ig M、Ig A的下降与 NO的升高呈负相关 (P<0 .0 5 )。C4无显著性变化。结论 NO与婴儿肝炎综合征的严重程度有关且在一定程度上能调节体液免疫
Objective To measure the serum immunoglobulin G (Ig G), immunoglobulin A (Ig A), immunoglobulin M (Ig M), complement C3, complement C4 and nitric oxide in acute and convalescent infants with infant hepatitis syndrome (NO) levels in order to understand the changes of various factors and their relationship with the disease progression. Methods Ig G, Ig A, Ig M, C3, C4 Rate-nephelometry. NO end method. Results Serum levels of Ig G, Ig A and C3 were significantly decreased and the level of NO was significantly increased in the acute stage of infantile liver disease. Compared with the acute stage, Ig G, Ig M, Ig A and C3 All increased, but the indexes except Ig M were lower than the normal control; NO decreased but still higher than the normal control. During the course of disease, the decrease of Ig G, Ig M and Ig A was negatively correlated with the increase of NO (P <0.05). C4 no significant change. Conclusion NO is related to the severity of infant hepatitis syndrome and to a certain extent can regulate humoral immunity