分别皮下注射ＩＬ－６３．３×１０６μ／ｋｇ／ｄ和０．１７×１０６μ／ｋｇ／ｄ，不同时间的雌雄小鼠合笼交配。实验观察动物的一般状况，体重变化，受孕率，活胎数，死胎数，活胎重，胎仔的内脏和骨骼变化，自然产仔数，Ｆ１代仔鼠的生长发育等。实验组与对照组比较：高剂量组对小鼠早期胚胎有影响，但对Ｆ１代仔数的生长发育无影响。未见有ＩＬ－６的低剂量引起的生殖毒副作用 IL-63.3 × 106μ / kg / d and 0.17 × 106μ / kg / d were injected subcutaneously, and males and females at different times were caged. The experiment was conducted to observe the general condition, weight change, pregnancy rate, number of live fetus, number of stillbirth, live weight, visceral and skeletal changes of fetal, natural litter size, growth and development of F1 offspring rats. The experimental group and the control group: high-dose group had an impact on the early embryo of mice, but no effect on F1 generation growth. No toxic or side effects of low doses of IL-6 were observed