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选取wister大鼠8只作为实验动物,分成8组,按照30 mg/kg(以氟苯尼考计)体重单次肌肉注射氟苯尼考琥珀酸钠,给药后间隔一定时间采血,以HPLC测定血样中氟苯尼考琥珀酸钠、氟苯尼考以及氟苯尼考胺,用BAPP2.0软件对动力学参数进行统计分析.结果表明,单剂量肌内注射氟苯尼考琥珀酸钠后,氟苯尼考、氟苯尼考琥珀酸钠以及氟苯尼考胺药时数据符合一级吸收一室模型,其主要的动力学参数为:Tmax 1 h,0.5 h,8 h;Cmax 6.28,4.50,3.32μg/mL;Vd、AUC、CL/F(s)分别为0.77 mg/L、37.03μg/mL和0.26 L/h;1.05 mg/L、17.22μg/mL、0.62 L/h;0.75 mg/L、85.5μg/mL、0.07 L/h;同时研究还表明氟苯尼考琥珀酸钠进入大鼠体内后,在血液中各种酶的作用下能够迅速的转化为氟苯尼考且能够较快地达到血药浓度峰值,因此提示该产品起效快,维持血药浓度时间较长,在临床上适用于敏感菌所致的急性和重性感染.
Eight wister rats were selected as experimental animals and divided into 8 groups. According to a single intramuscular injection of florfenicol sodium succinate at a dose of 30 mg / kg (florfenicol), blood samples were taken at regular intervals after the administration. HPLC Determination of florfenicol sodium succinate, florfenicol and florfenicol amine in blood samples, and statistical analysis of kinetic parameters with BAPP2.0 software.The results showed that a single dose of intramuscular sodium florfenicol succinate The data of florfenicol, florfenicol sodium succinate and florfenicol were consistent with the first-order absorption one-compartment model. The main kinetic parameters were: Tmax 1 h, 0.5 h, 8 h; Cmax 6.28,4.50 and 3.32μg / mL respectively; Vd, AUC and CL / F (s) were 0.77 mg / L, 37.03μg / mL and 0.26 L / h, 1.05 mg / L, 17.22μg / mL and 0.62 L / ; 0.75 mg / L, 85.5μg / mL, 0.07 L / h; at the same time also showed that florfenicol sodium succinate into rats, the various enzymes in the blood can be quickly converted to florfenib Test and can quickly reach the peak plasma concentration, suggesting that the rapid onset of the product to maintain a longer plasma concentration, clinically applicable to acute and severe infections caused by susceptible strains.