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目的通过临床抽样调查,探讨与小儿高脂血症发病有关的危险因素,为小儿高脂血症的早期检测提供客观指标。方法北京大学第一医院儿科等于2004年9月,调查并分析了962名北京市景山学校在校学生(5~19岁)的血脂浓度,其中采用酶法测定总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)及低密度脂蛋白(LDL-C)等4项指标。采用坐高、腰围、上臂围、体重指数来反映身体肥胖程度,进一步分析了这些指标与血脂浓度的关系。结果在962名学生中,共检出高脂血症患儿122例,总检出率为12·7%。高脂血症组的坐高、腰围、上臂围、体重指数4项指标明显高于正常组,2组间差异有显著性(P<0·05);坐高、腰围、上臂围、体重指数等4项指标与甘油三酯均呈高度显著正相关(P<0·01),与高密度脂蛋白均呈高度显著负相关(P<0·01)。结论正常组与高脂血症组的坐高、腰围、上臂围、体重指数4项指标差异均有显著性;坐高、腰围、上臂围、体重指数均是影响甘油三酯和高密度脂蛋白浓度的危险因素。
Objective To investigate the risk factors related to the incidence of pediatric hyperlipidemia by clinical sampling survey and provide objective indicators for the early detection of pediatric hyperlipidemia. Methods The pediatric department of Peking University First Hospital was equal to September 2004. The blood lipid levels of 962 Beijing Jingshan school students (5-19 years old) were investigated and analyzed. Enzyme method was used to determine total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C) and other four indicators. Sit height, waist circumference, upper arm circumference, body mass index to reflect the degree of body fat, and further analysis of these indicators and the relationship between serum lipids. Results Among 962 students, 122 cases of hyperlipidemia children were detected, the total detection rate was 12.7%. There were significant differences in height, waist circumference, upper arm circumference and body mass index between the two groups (P <0.05) There was a highly significant positive correlation between four indicators and triglyceride (P <0.01), and a high significant negative correlation (P <0.01) with HDL. Conclusion There are significant differences in the four indexes of sitting height, waist circumference, upper arm circumference and body mass index between normal group and hyperlipidemia group. The height, waist circumference, upper arm circumference and body mass index all affect the triglyceride and high density lipoprotein Concentration of risk factors.