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目的:研究原发性高血压高尿酸血症相关因素,探讨高血尿酸与原发性高血压靶器官损害的关系。方法:选择2007-02/2008-08住院的高血压患者306例,按尿酸水平分为高尿酸组及正常尿酸组,比较两组一般临床资料及血尿酸水平与高血压靶器官损害情况,分析高尿酸血症的相关危险因素。结果:尿酸与三酰甘油、血压等呈正相关(P<0.05);颈动脉病变、视网膜病变与血尿酸呈正相关,合并左心室肥厚、脑血管意外、肾脏损害者,血尿酸值也显著升高。结论:原发性高血压尿酸与多因素相关,高尿酸血症与高血压靶器官损害密切相关,表明高尿酸血症在高血压病的发生发展过程中起重要的作用。
Objective: To study the related factors of hypertensive hyperuricemia and to explore the relationship between hyperuricemia and the target organ damage of essential hypertension. Methods: A total of 306 hypertensive patients admitted in our hospital from 2007-02 / 2008-08 were divided into hyperuricemia group and normal uric acid group according to the level of uric acid. The clinical data, serum uric acid level and target organ damage were compared between the two groups Hyperuricemia related risk factors. Results: There was a positive correlation between uric acid and triglyceride and blood pressure (P <0.05). Carotid artery and retinopathy were positively correlated with serum uric acid. Serum and uric acid levels were also significantly increased in patients with left ventricular hypertrophy, cerebrovascular accident and renal damage . Conclusions: Uric acid in essential hypertension is related to many factors. Hyperuricemia is closely related to target organ damage in hypertension, indicating that hyperuricemia plays an important role in the development of hypertension.