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过去许多研究曾表明,释放孕酮或其他孕激素的宫内节育器(IUD)的作用方式,至少部分取决于IUD释放的激素对子宫内膜功能变化所发生的影响。尽管多数使用IUD妇女的排卵和黄体功能是正常的,但子宫内膜形态处于完全的抑制状态。以后又有报告进一步证实,带酮孕IUD妇女的子宫内膜比不带孕酮者萎缩的更严重。本文则通过对子宫内膜细胞液中女性激素浓度变化的研究,进一步解释组织对循环性激素水平变化不敏感的原因。试验选择11名带孕酮IUD志愿者,受试妇女每年换1次IUD,平均用药时间为4.1年。在周期的卵泡期刮取子宫内膜活检,术后立即将组织标本(100～300mg)置塑料袋中,液氮冷冻,-70℃贮
Many studies in the past have shown that the mode of action of IUDs that release progesterone or other progestins depends at least in part on the effects of hormones released by IUDs on changes in endometrial function. Although most women who use IUD have normal ovulation and luteal function, the endometrial morphology is completely inhibited. Later reports further confirmed that women with keto-IUD endometrial more than those without progesterone atrophy. This article through the endometrial cell fluid in female hormone concentration changes in the study to further explain the organization is not sensitive to changes in circulating hormone levels reasons. A total of 11 volunteers with progesterone IUD were enrolled in this study. The women under study changed their IUD once a year for an average of 4.1 years. Endometrial biopsy was performed at the follicular phase of the cycle. Tissue samples (100-300 mg) were immediately placed in plastic bags and frozen in liquid nitrogen and stored at -70 ° C