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目的 探讨长期使用不同剂量的免疫抑制剂对肾移植受者细胞因子谱系的影响。方法 采用多种高灵敏度试剂盒 ,分别对存活 3年以上 ,且长期使用低剂量免疫抑制剂者 (低剂量组 )、使用常规剂量者 (常规组 )和慢性移植肾功能丧失者 (失功组 )的外周血多种细胞因子进行检测 ,分析细胞因子谱系的变化与临床用药量和移植效果的关系。结果 长期存活且肾功能正常者的白细胞介素4(IL 4)水平升高 ,在低剂量组升高尤其明显 ,而失功组明显降低 ;各组白细胞介素 2受体 (IL 2R)水平移植后均有升高 ,但低剂量组与正常人接近 ,失功组升高最明显 ;各组白细胞介素 1 0 (IL 1 0 )和转化生长因子 β1移植后均下降 ,前者在低剂量组和常规组中水平相近 ,后者以失功组下降最为明显。 结论 细胞因子谱系与免疫抑制剂的用量和移植肾功能有关 ,监测IL 2R和IL 4可能对评价肾移植受者的免疫状态有帮助
Objective To investigate the effect of long-term use of different doses of immunosuppressive agents on cytokine lineages in renal transplant recipients. Methods A variety of high sensitivity kits were used to investigate the effects of low-dose immunosuppressive agents (low dose), those with conventional dose (routine group) and chronic kidney transplant recipients ) In peripheral blood of a variety of cytokines were detected, analysis of changes in cytokine lineages and the clinical dose and the relationship between transplantation. Results The long-term survival and normal renal function in patients with elevated levels of interleukin 4 (IL 4R) in the low-dose group was particularly evident, while the loss of power group was significantly lower; each group of interleukin 2 receptor (IL 2R) levels The levels of interleukin-10 (IL-10) and transforming growth factor-beta1 (TGF-β1) were decreased in all groups after transplantation, while the former was significantly lower in low-dose group The level of the group is similar to that of the conventional group, and the latter is the most obvious in the group of losing power. Conclusions Cytokine profiles are associated with the dose of immunosuppressive agents and graft function, and monitoring IL 2R and IL 4 may be helpful in assessing the immune status of recipients with renal transplant recipients