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卡托普利(captopril,CPT,巯甲丙脯酸)是第一代血管紧张素转化酶(ACE)抑制剂,近年来在肾病治疗中的应用屡见报道,本文仅就其作一综述。 1 糖尿病性肾病 糖尿病性肾病是糖尿病微血管病变之一,目前尚无特效方法。CPT可控制糖尿病性肾病的进展或恶化,保持血压正常与高血压糖尿病性肾病患者的肾功能。409例糖尿病性肾病患者,口服CPT 25mg,tid,结果血压增高的危险性降低了48.5％,死亡、透析或肾移植的危险性降低了50.5％。苏如松,李荣,赵爱国按随机2×2因子原则,设计研究了CPT和硝苯地平合用对Ⅱ型糖尿病肾病合并高血压36例患者进行治疗,取得满意疗效。研究表明,CPT治疗糖尿病肾脏损伤优于其它抗高血压
Captopril (captopril, captopril) is the first generation of angiotensin-converting enzyme (ACE) inhibitors, in recent years in the treatment of nephropathy frequently reported, this article only to make a review. 1 Diabetic nephropathy Diabetic nephropathy is one of the diabetic microangiopathy, there is no specific method. CPT can control the progress or worsening of diabetic nephropathy, maintain normal blood pressure and renal function in patients with hypertensive diabetic nephropathy. 409 patients with diabetic nephropathy, oral CPT 25mg, tid, resulting in an increase of 48.5% lower the risk of blood pressure, death, dialysis or kidney transplantation reduced the risk of 50.5%. SU Ru-Song, LI Rong, ZHAO Ai-Guo According to the principle of random 2 × 2 factor, 36 patients with type Ⅱ diabetic nephropathy complicated with hypertension were treated with CPT and nifedipine, and satisfactory results were obtained. Studies have shown that CPT treatment of diabetic kidney damage than other antihypertensive