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目的探讨c－myc基因与骨肉瘤发生发展及预后的关系。方法用S－P免疫络化法，对50例骨肉瘤石蜡包埋标本进行了c－mycp67表达水平的研究。结果骨肉瘤c－mycp67蛋白阳性率高达72％，c－mycp67表达与骨肉瘤患者性别、年龄、病理类型、肿瘤分期等均无明显关系，而c－mycp67阳性表达骨肉瘤患者的3年生存率低于c－mycp67阴性表达者。结论c－mycp67表达可能对判断骨肉瘤预后有一定意义。
Objective To investigate the relationship between c-myc gene and the occurrence, development and prognosis of osteosarcoma. Methods The expression of c-mycp67 in paraffin-embedded specimens of 50 cases of osteosarcoma was studied by S-P immunohistochemical method. Results The positive rate of c-mycp67 protein in osteosarcoma was as high as 72%. The expression of c-mycp67 was not significantly related to the gender, age, pathological type, and tumor stage of osteosarcoma. The 3-year survival rate of c-mycp67-positive osteosarcoma was not significant. Lower than c-mycp67 negative expression. Conclusion The expression of c-mycp67 may have a certain significance in judging the prognosis of osteosarcoma.