妊娠期孕母用药不当可以引起流产、早产或造成胎儿畸形,也可以引起分娩障碍,因此孕妇合理用药对“优孕”、“优生”意义重大,现就妊娠期心血管疾病用药作一讨论。 一、抗高血压药 甲基多巴 抗高血压效果良好,对孕母无明显副作用,可以通过胎盘,在孕母和胎儿血浆中浓度几乎一致,每日剂量4g单用或与噻嗪类利尿剂合用,没有发现先天畸形的报道,出生婴儿的智商和血压与无高血压妊妇所生婴儿无差异,有人提出甲基多巴可以作为妊娠期抗高血压首选药。 可乐宁 适用于二期以上高血压,不减少肾血流,因偶可引起心功过缓、传导阻滞,长期用药突然停药可出现高血压危象,故不推荐妊期长时间应 Improper treatment of pregnant women during pregnancy can cause miscarriage, premature birth or cause fetal malformations, can also cause birthing disorders, so pregnant women rational use of drugs on the “excellent pregnancy”, “eugenics” is of great significance, now on the use of drugs for a discussion of cardiovascular disease. First, the antihypertensive drug methyldopa antihypertensive effect is good, no significant side effects on the pregnant mother, you can pass the placenta, the concentration in pregnant mother and fetal plasma concentration is almost the same, the daily dose of 4g alone or with thiazide diuretic Combination of agents, no congenital malformations were reported, the birth of a baby’s IQ and blood pressure without hypertension and no difference in the birth of pregnant women, it was suggested that methyldopa can be used as the first choice for anti-hypertensive drugs during pregnancy. Clonidine for more than two hypertension, does not reduce renal blood flow, even can cause bradycardia, conduction block, long-term withdrawal sudden withdrawal may appear hypertensive crisis, it is not recommended for a long period of pregnancy should