SARS冠状病毒蛋白酶是一种用于抗病毒治疗的主要靶点。有研究表明,苯并三唑酯类对此酶具有效的抑制作用,而这些化合物却是洛匹那韦(lopinavir)衍生物合成中的中间体。自从90年代中期发现HIV-1蛋白酶以来,随着数百个抑制剂复合物晶体结构的确定,这种蛋白酶已成为研究得最透彻的 SARS coronavirus protease is a major target for antiviral therapy. Studies have shown that benzotriazole esters have an effective inhibitory effect on this enzyme, and these compounds are intermediates in the synthesis of lopinavir derivatives. Since the discovery of HIV-1 protease in the mid-1990s, the protease has been the most studied with the crystal structure of hundreds of inhibitor complexes