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目的：考察羟萘甲酸沙美特罗的平喘作用，并与硫酸沙丁胺醇进行比较。方法：采用离体豚鼠气管螺旋条法和在体豚鼠药物引喘法。结果：羟萘甲酸沙美特罗具有松弛豚鼠气管平滑肌作用，ｐＤ２为９．０４±０．１２；非竞争性拮抗乙酰胆碱（Ａｃｈ）所致的豚鼠离体气管平滑肌收缩，ＩＣ５０为（１５．７±１．６４）×１０－１０ｍｏｌ／Ｌ；延长Ａｃｈ和Ｈｉｓ所致豚鼠哮喘的潜伏期。其作用呈现剂量依赖性，用药后０．５，１．５，６ｈ对于豚鼠喘息性抽搐保护作用的ＥＤ５０及其９５％的可信限分别每只为６．７９（３．９１～９．９８），５．１６（２．９４～９．０７），５．９２（３．４０～９．３１）μｇ。结论：羟萘甲酸沙美特罗具有平喘作用，其作用强度和作用时间均显著强于硫酸沙丁胺醇（Ｐ＜０．０５）。
OBJECTIVE: To investigate the antiasthmatic effect of salmeterol xinafoate and compare it with salbutamol sulfate. Methods: The guinea pig trachea spiral strip method and in vivo guinea pig drug asthma method. RESULTS: Salmeterol xinafoate had the effect of relaxing the bronchial smooth muscle of guinea pigs with a pD2 of 9.04 ± 0.12. The non-competitive antagonism of acetylcholine (Ach) induced guinea pig tracheal smooth muscle contraction with IC50 of (15.7 ± 1.64) × 10-10mol / L; prolonged Ach and His-induced guinea pig asthma latency. The effect was dose-dependent. The ED50 and 95% confidence limits of 0.5, 1.5, and 6 h for the protection of asthmatic convulsions in guinea pigs were 6.79 (3.91-9.98 ), 5.16 (2.94 ~ 9.07), 5.92 (3.40 ~ 9.31) μg. Conclusion: Salmeterol xinafoate has an antiasthmatic effect, its intensity and action time are significantly stronger than salbutamol sulfate (P <0.05).