氨基糖苷类抗生素对需氧革兰氏阴性杆菌以及葡萄球菌等具有良好抗菌作用 ,但由于其明显的耳、肾毒性 ,临床应用受到限制。根据该类药物为浓度依赖性抗菌药物、具有较长的抗生素后效应和可诱导细菌产生适应性耐药等药效学特点 ,提出了一日量 1次给药方案。和传统给药方案相比 ,至少疗效相等、安全性相同或更好、医疗费用降低、治疗药物监测更方便 ,值得进一步扩大临床试验验证其有效性和安全性 Aminoglycoside antibiotics have good antibacterial activity against aerobic gram-negative bacilli and staphylococcus aureus, but their clinical applications are limited due to their obvious ototoxicity and nephrotoxicity. According to the class of drugs as concentration-dependent antibacterial drugs, with longer antibiotic-induced effects and can induce bacterial resistance and other pharmacodynamic characteristics, put forward a dose of 1 dose program. At least equal efficacy, same or better safety, lower medical costs and more convenient monitoring of therapeutic drugs than conventional dosing regimens are worth further clinical trials to validate their effectiveness and safety