论文部分内容阅读
目的 研究充血性心力衰竭 (CHF)患者血清生长激素 (GH) /胰岛素样生长因子 - (IGF- )轴水平的变化 ,探讨血清 GH/ IGF- 轴水平与病因、心功能、左室射血分数 (L VEF)、X线心胸比率 (CTR)等指标的相互关系。 方法 CHF患者 6 6例 ,按 NYHA心功能分级标准 级 2 3例 , 级 30例 , 级 1 3例。检测血 GH、IGF- ,以 lg(IGF- / GH)作为生长激素敏感性指标 ,超声心动图测 L VEF,胸部 X线计算 CTR。 结果 GH在心功能 ～ 级组分别为 (0 .38± 0 .5 2 ) ,(0 .95± 1 .1 4 ) ,(1 .75± 1 .2 5 )μg/ L ,心功能 级组分别与 级组及 级组比较 ,差异有显著性 (P<0 .0 5 ,t’检验 ,下同 ) ,而 级组与 级组比较 ,差异无显著性 (P>0 .0 5 )。IGF- 在心功能 ～ 级组分别为 (1 97.97± 1 0 1 .89) ,(1 0 4 .1 9± 31 .81 )和 (5 2 .1 6± 2 3.6 9)μg/ L ,两两相比 ,差异有显著性 (P<0 .0 5 )。 lg(IGF- / GH)在心功能 ～ 级组中分别为 (3.1 3± 0 .6 8) ,(2 .38± 0 .70 ) ,(1 .5 5± 0 .5 3) ,两两相比 ,差异有显著性(P<0 .0 5 ) ,lg(IGF- / GH)分别与 L VEF及 CTR呈线性相关 (P<0 .0 5 )。不同病因 CHF患者血 GH、IGF- 、lg(IGF- / GH)水平比较 ,差异无显著性 (P>0 .0 5 )。 结论 CHF患者随?
Objective To investigate the changes of serum GH / IGF- axis in patients with congestive heart failure (CHF) and to explore the relationship between serum GH / IGF-axis and etiology, cardiac function, left ventricular ejection fraction (L VEF), chest X-ray ratio (CTR) and other indicators of the interrelationship. Methods Sixty-six patients with CHF were enrolled. According to NYHA functional class 23 cases, grade 30 and grade 13. Blood GH and IGF-1 levels were measured as growth hormone sensitivity index (lg (IGF- / GH), echocardiography was used to measure L VEF and chest X-ray was used to calculate CTR). Results The levels of GH in heart function group were (0.38 ± 0.52), (0.95 ± 1.14) and (1.75 ± 1.25) μg / L, respectively Compared with the grade group and the grade group, the difference was significant (P <0.05, t ’test, the same below), but there was no significant difference between the grade group and the grade group (P> 0.05). The levels of IGF-1 in cardiac function-grade group were (1 97.97 ± 1 0 1 .89), (104 ± 1 9 ± 31 .81) and (52 2 ± 6 3.6 9) μg / Compared with the difference was significant (P <0. 05). The levels of IGF- / GH in heart function group were (3.1 3 ± 0.68), (2.38 ± 0.70), (1.55 ± 0.53) The difference was significant (P <0.05). Lg (IGF- / GH) was linearly correlated with L VEF and CTR (P <0.05). There was no significant difference in GH, IGF-, Ig (IGF- / GH) levels in patients with different etiologies of CHF (P> 0.05). Conclusion CHF patients with?