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作者采用放射免疫法对78例急性脑损伤病人进行血浆和脑脊液(CSF)中内皮素(ET)含量测定。结果表明,脑损伤后两者 ET 含量均显著增加(P<0.01),CEF 中 ET 含量测定较血浆更准确地反映脑损伤的程度和范围,当 CSF 中 ET 含量大于84.12±5.82ng/L 时,提示预后不良。作者对 ET 增高的原因和病理作用进行讨论。
The authors used radioimmunoassay in 78 patients with acute brain injury in plasma and cerebrospinal fluid (CSF) in the determination of endothelin (ET) content. The results showed that the content of ET in both groups increased significantly (P <0.01). The content of ET in CEF reflected the extent and range of brain injury more accurately than the plasma. When the content of ET in CSF was more than 84.12 ± 5.82 ng / L , Suggesting that the prognosis is poor. The authors discuss the causes and pathological effects of elevated ET.