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目的 观察白细胞介素 13 (IL- 13 )在急性肾小球肾炎 (AGN)和紫癜性肾炎 (HSPN)患儿中的变化 ,并探讨其临床意义。方法 应用 EL ISA法检测 2 4例 AGN和 2 0例 HSPN患儿外周血单个核细胞 (PBMC)培养上清中 IL - 13的水平。结果 AGN急性期和 HSPN活动期 PBMC培养上清中 IL - 13水平显著高于恢复期和正常对照组 ,恢复期降至正常水平。结论 IL - 13在 AGN和 HSPN发病机制中发挥着一定的作用。 PBMC培养上清中 IL - 13水平的变化可作为观察病情活动状态的一个免疫学指标
Objective To observe the changes of interleukin-13 (IL-13) in children with acute glomerulonephritis (AGN) and purpuric nephritis (HSPN) and to investigate its clinical significance. Methods IL - 13 levels in peripheral blood mononuclear cells (PBMCs) of 24 children with AGN and 20 children with HSPN were detected by ELISA. Results The level of IL - 13 in the culture supernatant of AGN and HSPN active stage was significantly higher than that of the recovery and normal control group, and the recovery time was reduced to normal level. Conclusion IL - 13 plays a role in the pathogenesis of AGN and HSPN. The change of IL - 13 in the culture supernatant of PBMC can be used as an immunological indicator to observe the activity of the disease