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生存蛋白(survivin)属于凋亡抑制蛋白(IAP)家族成员,研究显示,生存蛋白是迄今为止发现的最强的凋亡抑制因子。生存蛋白在胚胎组织及恶性肿瘤中普遍表达,如胃癌、结直肠癌、乳腺癌、肺癌等;但在分化成熟的组织及癌旁正常组织中无表达,这一特点使得生存蛋白的靶向治疗具有良好特
Survivin is a member of the apoptosis inhibitory protein (IAP) family. Studies have shown that survivin is the strongest inhibitor of apoptosis found so far. Survivin protein is commonly expressed in embryonic tissues and malignant tumors, such as gastric cancer, colorectal cancer, breast cancer, and lung cancer. However, it is not expressed in differentiated and mature tissues and adjacent normal tissues. This feature makes targeted therapy for survivin proteins. Has a good special