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为了避免阴茎海绵体内注射血管活性药物的副反应及缺点,作者对经皮肤应用硝酸甘油(有力的平滑肌松弛剂)在强化勃起质量方面的作用进行了研究。26名夜间勃起测定全部异常的阳萎病人分别用硝酸甘油或安慰剂贴膏贴敷于阴茎干部,结果总共有21例(80.8％)呈硝酸甘油阳性反应,其中12例(46.2％)完全恢复满意性功能,9例(34.6％)部分有效,安慰剂贴膏5例呈阳性反应(1例完全有效,4例部分有效)。21例中17例能鉴别硝酸甘油及安慰剂之间的明显差别。21例阳性反应者应用至今已6月,完全有效及部分有效不变,仅4例因持续头痛而停用,硝酸甘油贴膏每24小时释放硝酸甘油10mg,每周用3次在性交前2～6小时用。作者认为硝酸甘油贴膏值得进一步试验,特别是对中度性功能障碍者。
In order to avoid the side effects and shortcomings of injecting vasoactive drugs in the penis, the authors investigated the role of transdermal application of nitroglycerin (potent smooth muscle relaxant) in enhancing erectile quality. Twenty-six erectile dysfunction patients with impaired nocturnal erection were treated with nitroglycerin or placebo patch, respectively. A total of 21 (80.8%) patients were positive for nitroglycerin, of which 12 (46.2%) recovered completely Satisfactory sexual function, 9 cases (34.6%) partially effective, placebo patch 5 cases were positive (1 cases were fully effective, 4 cases partially effective). Seventeen of 21 patients were able to identify significant differences between nitroglycerin and placebo. Twenty-one of the 21 responders had been in use until June, completely effective and partially effective, with only 4 discontinued due to persistent headache. Nitroglycerin was given 10 mg of nitroglycerine every 24 hours and 3 times weekly before sexual intercourse 2 ~ 6 hours use. The authors believe that nitroglycerin paste worth further testing, especially for those with moderate dysfunction.