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目的:探讨5-氟尿嘧啶植入剂腹腔化疗治疗晚期卵巢癌的效果。方法:将2008年1月-2009年12月我院收治的64例晚期卵巢癌患者随机分为两组。治疗组31例于肿瘤细胞减灭术中腹腔置入5-氟尿嘧啶植入剂;对照组33例仅行肿瘤细胞减灭术。两组均于腹部切口拆线后行静脉全身化疗,方案为奥沙利铂联合紫杉醇脂质体(力扑素)或多西他赛(艾素或斯曲帝)。结果:治疗组CR11例,PR14例,有效率80.6%,对照组CR8例,PR11例,有效率57.6%。腹痛、腹泻发生率在治疗组为29.0%,对照组为9.1%,两组比较差异有显著性(P<0.05),骨髓抑制、恶心、呕吐、肝毒性、周围神经毒性的发生率在两组无显著性差异,无肾功能损害。结论:5-氟尿嘧啶植入剂腹腔化疗安全、有效,联合静脉化疗可以提高晚期卵巢癌的缓解率。
Objective: To investigate the effect of 5-fluorouracil intraperitoneal chemotherapy on advanced ovarian cancer. Methods: 64 patients with advanced ovarian cancer admitted to our hospital from January 2008 to December 2009 were randomly divided into two groups. Thirty-one patients in the treatment group were treated with 5-fluorouracil intraperitoneal injection in tumor cytoreductive surgery; 33 patients in the control group were only treated with cytoreductive surgery. Both groups were treated with intravenous systemic chemotherapy after removal of the abdominal incision. The regimen was oxaliplatin combined with paclitaxel liposomes (docetaxel) or docetaxel (bezosin or radix). Results: The treatment group CR11 cases, PR14 cases, the effective rate was 80.6%, CR8 cases in the control group, PR11 cases, the effective rate was 57.6%. The incidence of abdominal pain and diarrhea was 29.0% in the treatment group and 9.1% in the control group, with significant difference between the two groups (P <0.05). The incidence of bone marrow depression, nausea and vomiting, hepatotoxicity and peripheral neurotoxicity were significantly lower in the two groups No significant difference, no renal damage. Conclusion: 5-fluorouracil intraperitoneal chemotherapy is safe and effective, and combined with intravenous chemotherapy can improve the remission rate of advanced ovarian cancer.