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目的:观察TGP治疗活动性RA疗效及安全性。方法:将活动性RA患者80例,随机分为治疗组和对照组。治疗组予以TGP和LEF;对照组单用LEF;观察患者关节症状改善程度、血沉变化情况及药物副作用。结果:治疗第4周治疗组患者关节症状改善50%,明显高于对照组的30%(P<0.05),并且第1周时治疗组有效率60%,明显高于对照组37%(P<0.01),此外TGP与LEF联合运用在治疗初期能较大幅度地降低血沉。在不良反应发生方面,治疗组仅出现轻度腹泻,且发生率低于10%,而对照组部分有患者出现了肝功能轻度异常。结论:TGP联合LEF较大幅度的降低血沉,改善症状,减轻抗风湿慢作用药物LEF对肝功影响,具保肝、护肝作用,缩短活动性类风湿关节症状改善的时间,且不良反应发生率低,使患者尽快缓解症状,且耐受性好。
Objective: To observe the efficacy and safety of TGP in the treatment of active RA. Methods: 80 patients with active RA were randomly divided into treatment group and control group. The treatment group was given TGP and LEF; the control group was treated with LEF alone; the degree of improvement of joint symptoms, changes of erythrocyte sedimentation rate and drug side effects were observed. Results: In the fourth week of treatment, the joint symptom was improved by 50% in the treatment group, which was significantly higher than that in the control group (P <0.05), and the effective rate was 60% in the first week when the treatment group was significantly higher than that in the control group (P <0.01). In addition, the combination of TGP and LEF can significantly reduce ESR in the early stage of treatment. In the incidence of adverse reactions, the treatment group showed only mild diarrhea, and the incidence of less than 10%, while some patients in the control group had mild liver dysfunction. CONCLUSION: TGP combined with LEF significantly reduces erythrocyte sedimentation rate, ameliorated symptoms and relieved the effect of anti-rheumatoid drug LEF on liver function, protected liver and liver, shortened the time of active rheumatoid arthritis, and the rate of adverse reactions Low, so that patients relieve symptoms as soon as possible, and well tolerated.