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病因和发病机理非特异性炎症性肠病(NIBD)流行病学调查示工业发达国家和地区患病率较高,有逐年上升趋势。很多资料说明发病原因与环境因素有关。食物添加剂鹿角菜胶(car-rageenans)可能对NIBD的发病具有一定作用,豚鼠喂以1.4克/日30天后可出现结肠炎。溃结和Crohn病在青少年特别是女性中患病率较高。第二个较小的年龄高峰为55～60岁;这与易有肠缺血、对感染和自身免疫疾病抵抗力降低等因素有关。
Etiology and pathogenesis Non-specific inflammatory bowel disease (NIBD) Epidemiological survey showed a high prevalence in industrialized countries and regions, a rising trend year by year. A lot of information on the causes of the disease and environmental factors. Car-rageenans, a food additive, may have a role in the pathogenesis of NIBD, with colitis occurring in guinea pigs fed at 1.4 g / day for 30 days. Crohn’s disease and Crohn’s disease have a higher prevalence among adolescents, especially women. The second, younger age peak is 55 to 60 years old; this is associated with a predisposition to intestinal ischemia and reduced resistance to infection and autoimmune diseases.