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目的探索直接激光打印(DLMS)种植体在糖尿病小型猪模型中的早期骨结合情况。方法以6只小型猪为研究对象,耳缘静脉一次性注射链脲佐菌素(STZ)水溶液150 mg/kg建立糖尿病模型,于糖尿病小型猪双侧上颌骨前磨牙区牙槽嵴顶植入DLMS及微弧氧化(MAO)种植体,并于3个月及6个月分别取材做微计算机断层(Micro-CT)扫描及组织学检查。结果造模后小型猪血糖能稳定在较高水平(≥10 mmol/L),达到糖尿病标准(≥7 mmol/L)。Micro-CT及组织学检查可见,3个月时DLMS与MAO种植体骨结合差异有统计学意义(P<0.05),6个月时两组之间差异无统计学意义(P>0.05)。结论 DLMS种植体可加快糖尿病小型猪种植体骨结合速度。
Objective To explore the early osteointegration of direct laser printing (DLMS) implants in diabetic mini-pigs. Methods A total of 6 miniature pigs were selected as study objects. The diabetic rabbits were injected 150 mg / kg streptozotocin (STZ) once a day to establish the model of diabetes mellitus in the bilateral maxillary premolar area DLMS and MAO implants. Micro-computed tomography (CT) and histological examination were performed at 3 and 6 months respectively. Results The blood glucose level of miniature pigs stabilized at a higher level (≥10 mmol / L) and reached the standard of diabetes (≥7 mmol / L) after modeling. Micro-CT and histological examination showed that there was a significant difference in bone union between DLMS and MAO implants at 3 months (P <0.05). There was no significant difference between the two groups at 6 months (P> 0.05). Conclusion DLMS implant can accelerate the rate of osseointegration in diabetic miniature pigs.