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通过中国医院知识仓库 (CHKD)期刊知识库文献检索 ,对中国流行性感冒、麻疹、风疹、流行性腮腺炎、流行性脑脊髓膜炎疫苗预防接种后不良反应 (AEFI)进行分析和评价。结果显示 :近 10年来有关AEFI报告和研究呈逐年增加趋势 ,但多数是一般性病例报告 ,缺乏深入的流行病学调查研究。应根据AEFI与预防接种的因果关系的一致性、关联程度、时间联系、特异性、生物学合理性 ,来判断、分析感染性AEFI和非感染性AEFI。必须加强AEFI预防和处理措施 ,加强疫苗质量控制和管理 ,开展技术培训和监测 ,建立正常疫苗供应渠道和扩大预防接种的社会宣传、普及。
The AEFI was analyzed and evaluated in China by the Knowledge Base of Chinese Hospital Knowledge Warehouse (CHKD) after vaccination against influenza, measles, rubella, mumps and epidemic meningitis. The results showed that the reports and studies on AEFI in the recent 10 years showed a trend of increasing year by year, but most of them were general case reports and lack of in-depth epidemiological investigation. Infectious AEFI and non-infectious AEFI should be judged and analyzed according to the consistency of causality between AEFI and vaccination, the degree of association, the time connection, specificity and biological rationality. There is a need to strengthen AEFI prevention and treatment measures, strengthen vaccine quality control and management, carry out technical training and monitoring, establish a normal vaccine supply channel and expand publicity and popularization of vaccination.