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染色体易位在人类白血病的发病机理中起着重要作用。ＭＬＬ基因（又称ＨＲＸ，ＡＬＬ－１）定位于１１ｑ２３，在急性白血病中，与许多不同的伙伴基因发生易位。ＭＬＬ伙伴基因的克隆，不仅为诊断ＭＬＬ相关白血病提供了分子遗传标志，而且可以识别具有重要生物学功能的基因。
Chromosome translocation plays an important role in the pathogenesis of human leukemia. The MLL gene (also known as HRX, ALL-1) is located at 11q23 and translocates with many different partner genes in acute leukemia. The cloning of MLL partner genes not only provides molecular genetic markers for the diagnosis of MLL-associated leukemia, but also can identify genes with important biological functions.