骨肉瘤是指瘤细胞能直接形成骨样组织或骨质的恶性肿瘤,是一种死亡率及致残率极高的肿瘤,在全部恶性骨肿瘤中居于首位,其血行肺转移发生率高且早,进展迅速,容易出现复发和转移,是其致死的主要原因之一。多危及青少年,社会影响很大。目前,骨肉瘤治疗的靶标很多,但是被肿瘤特异性表 Osteosarcoma refers to the tumor cells can directly form bone-like tissue or bone of malignant tumors, is a high mortality rate and disability rate of tumors in all malignant bone tumors in the first place, the incidence of hematogenous lung metastasis and Early, rapid progress, prone to recurrence and metastasis, is one of the main causes of death. More endangered young people, social impact. At present, osteosarcoma treatment of many targets, but was tumor-specific table